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Panduan penyiapan dan pemberian terapi medikasi
Panduan penyiapan dan pemberian terapi medikasi
Dexamethasone Sodium Phosphate
Penyiapan
Sediaan
- 4mg/ml
Rekomendasi Pengenceran (Konsentrasi)
dapat digunakan tanpa diencerkan
Pelarut
Pemberian
Rekomendasi Akses
IV
IM
IM
Rekomendasi Durasi Pemberian
Stabilitas Obat Setelah Rekonstruksi
Keamanan
pH
7-8,5
pH risiko sedang (4,0-5,0 / 7,5-9,0)
Osmolaritas Sebelum Pengenceran
238-356 mOsm/kg
Osmolaritas rendah (<600)
Phlebitis
Tidak
Inkompatibilitas
- amikacin sulfate, daunorubicin hcl, Diphenhydramine HCl, Lorazepam, metoclopramide, doxopram hcl, Glycopyrrolate, Hydromorphone HCl, Midazolam HCl, Ondansetron HCl, Pantoprazole sodium, Blinatumomab, Ciprofloxacin, Fenoldopam mesylate, Idarubicin HCl, Isavuconazonium sulfate, Methotrexate sodium, Midazolam HCl, Topotecan HCl
Klasifikasi GHS
Irritant
Environment Hazard
Health Hazard
Manifestasi GHS
H315 (24.6%): Causes skin irritation [Warning Skin corrosion/irritation]
H317 (26.2%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H319 (25.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H334 (24.1%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
H335 (24.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
H360 (51.9%): May damage fertility or the unborn child [Danger Reproductive toxicity]
H360D (12.8%): May damage the unborn child [Danger Reproductive toxicity]
H373 (35.8%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
H410 (33.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
H317 (26.2%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H319 (25.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H334 (24.1%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
H335 (24.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
H360 (51.9%): May damage fertility or the unborn child [Danger Reproductive toxicity]
H360D (12.8%): May damage the unborn child [Danger Reproductive toxicity]
H373 (35.8%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
H410 (33.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
Sumber
- American Society of Health-System Pharmacists. 2021. ASHP® Injectable Drug Information: A Comprehensive Guide to Compatibility and Stability. 2021 Edition. eBook. American Society of Health-System Pharmacists. ISBN: 978-1-58528-690-4. doi.org/10.37573/9781585286850
- https://pubchem.ncbi.nlm.nih.gov/compound/5743