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Panduan penyiapan dan pemberian terapi medikasi
Panduan penyiapan dan pemberian terapi medikasi
Fentanyl
Risiko Phlebitis sedang
Kejadian Kadang-kadang (1/100 – 1/1000 kejadian)
Disarankan pengawasan selama infus berlangsung.
Penyiapan
Sediaan
- 0,5 mg/10 mL
Rekomendasi Pengenceran (Konsentrasi)
10 mcg/mL
Pelarut
- D5%
- NaCl 0.9%
Pemberian
Rekomendasi Akses
IV, IM
Rekomendasi Durasi Pemberian
Dewasa: Dosis 50-100 mcg diberikan 30-60 menit sebelum operasi (Anestesi)
Lansia: Dosis yang diberikan mungkin perlu diturunkan dan disesuaikan (Anestesi)
Dewasa: Dosis 0,5-1,5 mcg/kg/jam IV kontinu ( Nyeri Post Operasi)
Lansia: Dosis yang diberikan mungkin perlu diturunkan dan disesuaikan (Anestesi)
Dewasa: Dosis 0,5-1,5 mcg/kg/jam IV kontinu ( Nyeri Post Operasi)
Stabilitas Obat Setelah Rekonstruksi
7 hari dalam suhu ruang
Harus terhindar dari cahaya
Harus terhindar dari cahaya
Keamanan
pH
4,0-7,5
pH risiko sedang (4,0-5,0 / 7,5-9,0)
Osmolaritas Sebelum Pengenceran
281-299
Osmolaritas rendah (<600)
Phlebitis
Ya
Kadang-kadang (1/100 – 1/1000 kejadian)
Disarankan pengawasan selama infus berlangsung.
Disarankan pengawasan selama infus berlangsung.
Inkompatibilitas
-
Fluorouracil
-
Lidocaine HCl
-
Pentobarbital Sodium
-
Azithromycin
- Phenytoin Sodium
Klasifikasi GHS
Acute Toxicity
Irritant
Health Hazard
Manifestasi GHS
H300 (98.7%): Fatal if swallowed [Danger Acute toxicity, oral]
H310 (44.2%): Fatal in contact with skin [Danger Acute toxicity, dermal]
H317 (15.6%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H330 (48.1%): Fatal if inhaled [Danger Acute toxicity, inhalation]
H334 (15.6%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
H361 (15.6%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H362 (13%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]
H413 (11.7%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]
H310 (44.2%): Fatal in contact with skin [Danger Acute toxicity, dermal]
H317 (15.6%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H330 (48.1%): Fatal if inhaled [Danger Acute toxicity, inhalation]
H334 (15.6%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
H361 (15.6%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H362 (13%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]
H413 (11.7%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]
Sumber
- https://pubchem.ncbi.nlm.nih.gov/compound/3345
- American Society of Health-System Pharmacists. 2021. ASHP® Injectable Drug Information: A Comprehensive Guide to Compatibility and Stability. 2021 Edition. eBook. American Society of Health-System Pharmacists. ISBN: 978-1-58528-690-4. doi.org/10.37573/9781585286850