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Panduan penyiapan dan pemberian terapi medikasi
Amikacin Sulfate

Risiko Phlebitis sedang

Kejadian Kadang-kadang (1/100 – 1/1000 kejadian)
Disarankan pengawasan selama infus berlangsung.

Penyiapan

Sediaan

  • 250mg/ml (500mg/vial)

Rekomendasi Pengenceran (Konsentrasi)

100-200ml

Pelarut

  • D5%
  • NaCl 0.9%

Pemberian

Rekomendasi Akses

IM, IV

Rekomendasi Durasi Pemberian

Bayi: drip (dengan pengenceran) 1-2jam,
Anak-anak dan dewasa: drip (dengan pengenceran) 30-60 menit

Stabilitas Obat Setelah Rekonstruksi

24jam pada suhu 25C

Keamanan

pH

4,5 (3,5-5,5)
pH risiko sedang (4,0-5,0 / 7,5-9,0)

Osmolaritas Sesudah Pengenceran

500mg dalam 100ml D5% = 319mOsm/kg
500mg dalam 100ml NS 0,9% = 349mOsm/kg
Osmolaritas rendah (<600)

Phlebitis

Ya
Kadang-kadang (1/100 – 1/1000 kejadian)
Disarankan pengawasan selama infus berlangsung.

Inkompatibilitas

  • Aminophylline
  • Amphotericin B
  • Ampicillin Sodium
  • Cefazolin Sodium
  • Cefotaxime Sodium
  • Ceftazidime
  • Chlorothiazide Sodium
  • Dexamethasone Sodium Phosphate
  • Heparin Sodium
  • Oxacillin Sodium
  • Phenytoin Sodium
  • Pantoprazole Sodium
  • Allopurinol Sodium
  • Azithromycin
  • Cloxacillin Sodium
  • Defibrotide Sodium
  • Hetastarch
  • Ibuprofen Lysinate
  • Propofol

Klasifikasi GHS

Corrosives
Irritant
Health Hazard

Manifestasi GHS

H317 (75%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H318 (25%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
H332 (25%): Harmful if inhaled [Warning Acute toxicity, inhalation]
H360 (25%): May damage fertility or the unborn child [Danger Reproductive toxicity]
H372 (25%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

Sumber

  • American Society of Health-System Pharmacists. 2021. ASHP® Injectable Drug Information: A Comprehensive Guide to Compatibility and Stability. 2021 Edition. eBook. American Society of Health-System Pharmacists. ISBN: 978-1-58528-690-4. doi.org/10.37573/9781585286850
  • https://pubchem.ncbi.nlm.nih.gov/compound/37768