Kembali ke Daftar Obat
Panduan penyiapan dan pemberian terapi medikasi
Panduan penyiapan dan pemberian terapi medikasi
Digoxin (Injeksi)
Risiko Phlebitis rendah
Kejadian Jarang/Berpotensi (>1/1000 kejadian)
Tetap waspada, gunakan dengan prosedur standar
Penyiapan
Sediaan
- 250 mcg/ml
Rekomendasi Pengenceran (Konsentrasi)
dapat diberikan tanpa diencerkan atau diencerkan 4x volume
Pelarut
- D5%
- NaCl 0.9%
- WI
Pemberian
Rekomendasi Akses
IV
injeksi IM menyebabkan nekrosis otot dan nyeri
injeksi IM menyebabkan nekrosis otot dan nyeri
Rekomendasi Durasi Pemberian
10-20 menit. injeksi cepat menyebabkan vasokonstriksi sehingga terjadi hipertensi dan atau menurunkan aliran koroner
Stabilitas Obat Setelah Rekonstruksi
jika dilarutkan dalam rasio 1:250, stabil 48 jam suhu 20-25°C
Keamanan
pH
6.8-7.2
pH risiko rendah (5,0-7,5)
Osmolaritas Sebelum Pengenceran
9105 mOsm/kg
Osmolaritas tinggi (>900)
Harus melalui CVC
Harus melalui CVC
Phlebitis
Ya
Jarang/Berpotensi (>1/1000 kejadian)
Tetap waspada, gunakan dengan prosedur standar
Tetap waspada, gunakan dengan prosedur standar
Inkompatibilitas
-
Dobutamine HCl
-
Doxapram HCl
-
Pantoprazole sodium
-
Amiodarone HCl
-
Fluconazole
-
Foscarnet sodium
-
Insulin
-
Quinupristin–dalfopristin
- Telavancin HCl
Klasifikasi GHS
Irritant
Acute Toxicity
Health Hazard
Environment Hazard
Manifestasi GHS
H300+H330 (31.1%): Fatal if swallowed or if inhaled [Danger Acute toxicity, oral; acute toxicity, inhalation]
H300 (86.1%): Fatal if swallowed [Danger Acute toxicity, oral]
H319 (50.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H330 (79.5%): Fatal if inhaled [Danger Acute toxicity, inhalation]
H331 (10.7%): Toxic if inhaled [Danger Acute toxicity, inhalation]
H372 (44.3%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
H400 (54.9%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H300 (86.1%): Fatal if swallowed [Danger Acute toxicity, oral]
H319 (50.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H330 (79.5%): Fatal if inhaled [Danger Acute toxicity, inhalation]
H331 (10.7%): Toxic if inhaled [Danger Acute toxicity, inhalation]
H372 (44.3%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
H400 (54.9%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
Sumber
- https://www.medicines.org.uk/emc/product/5462/smpc#gref
- American Society of Health-System Pharmacists. 2021. ASHP® Injectable Drug Information: A Comprehensive Guide to Compatibility and Stability. 2021 Edition. eBook. American Society of Health-System Pharmacists. ISBN: 978-1-58528-690-4. doi.org/10.37573/9781585286850