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Panduan penyiapan dan pemberian terapi medikasi
Gentamicin Sulfate

Penyiapan

Sediaan

  • 80 mg/2 mL

Rekomendasi Pengenceran (Konsentrasi)

50-200 mL

Pelarut

  • D5%
  • NaCl 0.9%
  • RL

Pemberian

Rekomendasi Akses

IV/IM

Rekomendasi Durasi Pemberian

30-60 menit

Stabilitas Obat Setelah Rekonstruksi

48 jam pada suhu 20-25 derajat celcius

Keamanan

pH

3,0-5,5
pH risiko tinggi (<4 / >9)

Osmolaritas Sebelum Pengenceran

310
Osmolaritas rendah (<600)

Phlebitis

Tidak

Inkompatibilitas

  • Penicillins
  • Cephalosporins
  • Erythromycin
  • Heparin Sodium
  • Na Bicarbonate
  • Amphotericin B
  • Ampicillin Sodium
  • Cefazolin sodium
  • Cefepime HCl
  • Cefotaxime Sodium
  • Ceftazidime
  • Ceftriaxone Sodium
  • Cefuroxime Sodium
  • Clindamycin Phosphate
  • Cloxacillin Sodium
  • Cytarabine
  • Dopamine HCl
  • Fat Emulsion
  • Floxacillin Sodium
  • Furosemide
  • Fusidate Sodium
  • Nafcillin Sodium
  • Pantoprazole Sodium
  • Acyclovir Sodium
  • Allopurinol Sodium
  • Azithromycin
  • Cangrelor Tetrasodium
  • Filgrastim
  • Indomethacin Sodium Trihydrate
  • Iodipamide Meglumine
  • Hetastarch
  • Letermovir
  • Propofol
  • Quinupristin
  • Tedizolid Phosphate
  • Piperacillin Sodium

Klasifikasi GHS

Irritant
Health Hazard
Environment Hazard

Manifestasi GHS

H317 (47.6%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H334 (46.6%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
H360 (35.9%): May damage fertility or the unborn child [Danger Reproductive toxicity]
H360D (16.5%): May damage the unborn child [Danger Reproductive toxicity]
H372 (52.4%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
H400 (52.4%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410 (52.4%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Sumber

  • National center for biotechnology information. PubChem Compound Summary for CID 3467. https://www.mims.com/indonesia/drug/info/gentamicin?mtype=generic
  • American Society of Health-System Pharmacists. 2021. ASHP® Injectable Drug Information: A Comprehensive Guide to Compatibility and Stability. 2021 Edition. eBook.
  • American Society of Health-System Pharmacists. ISBN: 978-1-58528-690-4. doi.org/10.37573/9781585286850
  • https://pubchem.ncbi.nlm.nih.gov/compound/gentamicin