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Panduan penyiapan dan pemberian terapi medikasi
Panduan penyiapan dan pemberian terapi medikasi
Methylprednisolone Sodium Succinate
Penyiapan
Sediaan
- 40 mg/ vial
- 125 mg/vial
- 500 mg/vial
- 1 gram/vial
Rekomendasi Pengenceran (Konsentrasi)
- 2 mL pada 125mg/vial
- 8 mL pada 500mg/vial
- 16 mL pada 500mg/vial
Pelarut
- NaCl 0.9%
- RL
- WI
Pemberian
Rekomendasi Akses
IV
Rekomendasi Durasi Pemberian
bolus 1 menit
pada dosis diatas 250 mg diberikan minimal 5 menit
pada dosis diatas 250 mg diberikan minimal 5 menit
Stabilitas Obat Setelah Rekonstruksi
48 jam dibawah suhu 25 derajat celcius
Keamanan
pH
7,0-8,0
pH risiko sedang (4,0-5,0 / 7,5-9,0)
Osmolaritas Sebelum Pengenceran
400-440 mOsm/L
Osmolaritas rendah (<600)
Phlebitis
Tidak
Inkompatibilitas
-
Allopurinol Sodium
-
Aminophylline
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Amsacrine
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Calcium Gluconate
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Cisatracurium Besylate
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Diltiazem Hydrochloride
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Doxapram Hydrochloride
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Docetaxel
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Etoposide phosphate
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Gemcitabine HCl
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Glycopyrrolate
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Isavuconazonium sulfate
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Nafcillin sodium
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Ondansetron HCl
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Paclitaxel
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Plazomicin sulfate
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Potassium chloride
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Propofol
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Penicillin G sodium
-
Pantoprazole sodium
-
Rocuronium Bromide
-
Sargramostim
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Tigecycline
-
Vancomycin HCl
- Vecuronium Bromide
Klasifikasi GHS
Irritant
Health Hazard
Manifestasi GHS
H302 (27.4%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (27.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H351 (64.5%): Suspected of causing cancer [Warning Carcinogenicity]
H360 (64.5%): May damage fertility or the unborn child [Danger Reproductive toxicity]
H361 (33.9%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H312 (27.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H351 (64.5%): Suspected of causing cancer [Warning Carcinogenicity]
H360 (64.5%): May damage fertility or the unborn child [Danger Reproductive toxicity]
H361 (33.9%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
Sumber
- https://www.medicines.org.uk/emc/product/100417/smpc
- https://pubchem.ncbi.nlm.nih.gov/compound/23680530