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Panduan penyiapan dan pemberian terapi medikasi
Metronidazole

Penyiapan

Sediaan

  • 500 mg/100 mL

Rekomendasi Pengenceran (Konsentrasi)

Pelarut

Pemberian

Rekomendasi Akses

IV

Rekomendasi Durasi Pemberian

20-60 menit

Stabilitas Obat Setelah Rekonstruksi

Segera dipakai setelah dibuka

Keamanan

pH

4,5-6,0
pH risiko rendah (5,0-7,5)

Osmolaritas Sebelum Pengenceran

308
Osmolaritas rendah (<600)

Phlebitis

Tidak

Inkompatibilitas

  • Aztreonam
  • Cefamandole Nafate
  • Cefoxifitin
  • Penicilin G
  • Amoxicillin sodium–clavulanate potassium
  • Aztreonam
  • Fat emulsion
  • Filgrastim
  • Oritavancin diphosphate
  • Pemetrexed disodium
  • Quinupristin–dalfopristin

Klasifikasi GHS

Irritant
Health Hazard

Manifestasi GHS

H302 (15.3%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (16.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H332 (16.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]
H341 (53.7%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
H350 (49.7%): May cause cancer [Danger Carcinogenicity]
H351 (34.5%): Suspected of causing cancer [Warning Carcinogenicity]
H373 (29.4%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
H412 (39.5%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Sumber

  • https://www.medicines.org.uk/emc/product/1842/smpc
  • American Society of Health-System Pharmacists. 2021. ASHP® Injectable Drug Information: A Comprehensive Guide to Compatibility and Stability. 2021 Edition. eBook. American Society of Health-System Pharmacists. ISBN: 978-1-58528-690-4. doi.org/10.37573/9781585286850