Kembali ke Daftar Obat

Panduan penyiapan dan pemberian terapi medikasi
Midazolam

Risiko Phlebitis rendah

Kejadian Jarang/Berpotensi (>1/1000 kejadian)
Tetap waspada, gunakan dengan prosedur standar

Penyiapan

Sediaan

  • 1 mg/mL
  • 5mg/ml

Rekomendasi Pengenceran (Konsentrasi)

1mg/ml

Pelarut

  • NaCl 0.9%

Pemberian

Rekomendasi Akses

IV
IM

Rekomendasi Durasi Pemberian

Titrasi sesuai dosis dan berat badan pasien
Bolus 0,2mg/kgBB dalam 30 detik untuk induksi anestesi

Stabilitas Obat Setelah Rekonstruksi

72 jam pada suhu 25 derajat celcius

Keamanan

pH

2,9-3,7
pH risiko tinggi (<4 / >9)

Osmolaritas Sebelum Pengenceran

275-305
Osmolaritas rendah (<600)

Phlebitis

Ya
Jarang/Berpotensi (>1/1000 kejadian)
Tetap waspada, gunakan dengan prosedur standar

Inkompatibilitas

  • Amoxicillin sodium
  • Ketoconazole
  • Itraconazole
  • Voriconazole
  • Clarithromucin
  • Telithromycin
  • Boceprevir
  • Nefazodone
  • Aciclovir
  • Albumin
  • Alteplase
  • Aminophylline
  • Acetazolam Disodium
  • Dexamethasone sodium phosphate
  • Dimenhydrinate
  • Diazepam
  • Enoximone
  • Fluorouracil
  • Imipenem
  • Heparin sodium
  • Mezlocilin Sodium
  • Pantoprazole sodium
  • Phenobarbital Sodium
  • Phenytoin Sodium
  • Potassium Canrenoate
  • Ranitidine HCl
  • Sulbactam Sodium
  • Sodium bicarbonate
  • Theophylline
  • Trometamol
  • Urokinase

Klasifikasi GHS

Acute Toxicity
Irritant
Health Hazard
Environment Hazard

Manifestasi GHS

H301 (77.9%): Toxic if swallowed [Danger Acute toxicity, oral]
H302 (22.1%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (28.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H317 (27.3%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H334 (27.3%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
H361 (16.9%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H362 (14.3%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]
H411 (23.4%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard

Sumber

  • https://www.medicines.org.uk/emc/product/6419/smpc#gref
  • American Society of Health-System Pharmacists. 2021. ASHP® Injectable Drug Information: A Comprehensive Guide to Compatibility and Stability. 2021 Edition. eBook. American Society of Health-System Pharmacists. ISBN: 978-1-58528-690-4. doi.org/10.37573/9781585286850